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Hi everyone- I know you all work in nhs so likely to know this already but just in case you don’t this alert is from my pal who is a pharmacist locally in Yorkshire . See below
Message from my pal who is a pharmacist locally see below:
We have just been sent a medical alert that no one is to use anti inflammatories (eg ibuprofen , Voltarol, naproxen and there are others) for pain or high temperature. Use paracetamol instead. There seems to be a link between severe cases of covid19 affecting people with no underlying illnesses and taking anti inflammatories. Initial reports started coming from French Drs on Friday. This has been confirmed by infectious diseases consultants here - there are 4 people in ICU in Cork who have no underlying illnesses - all were taking anti inflammatories and there are concerns this has caused a more severe illness. We have been asked to spread the message. French tv and radio apparently broadcast the same warning today.
One of the factors was that most Italian patients took ibuprofen at home. They combine the virus and ibuprofen in the laboratory and came to the conclusion that the administration of ibuprofen accelerates the multiplication of the virus and that it is related to a more serious course of the disease. They recommend avoiding ibuprofen and other NSAIDS for fever, I guess similar to the association of aspirin in chicken pox leading to Reye's syndrome.
Message from my pal who is a pharmacist locally see below:
We have just been sent a medical alert that no one is to use anti inflammatories (eg ibuprofen , Voltarol, naproxen and there are others) for pain or high temperature. Use paracetamol instead. There seems to be a link between severe cases of covid19 affecting people with no underlying illnesses and taking anti inflammatories. Initial reports started coming from French Drs on Friday. This has been confirmed by infectious diseases consultants here - there are 4 people in ICU in Cork who have no underlying illnesses - all were taking anti inflammatories and there are concerns this has caused a more severe illness. We have been asked to spread the message. French tv and radio apparently broadcast the same warning today.
One of the factors was that most Italian patients took ibuprofen at home. They combine the virus and ibuprofen in the laboratory and came to the conclusion that the administration of ibuprofen accelerates the multiplication of the virus and that it is related to a more serious course of the disease. They recommend avoiding ibuprofen and other NSAIDS for fever, I guess similar to the association of aspirin in chicken pox leading to Reye's syndrome.
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Pei-Chi Lo mark this message contains personal perspective
｜originally written by Pei-Chi Lo
■「Cork醫院四名病人因服用抗炎藥病情加重」部分：錯誤，IDSI已澄清此為假消息。
■「ibuprofen等抗炎藥加重COVID-19病情」部分：學界尚無定論：
1.Lancet一篇通訊評論的確提及ibuprofen會增加ACE II促進COVID-19的感染；並認為使用這些藥物治療心臟病、高血壓、糖尿病的患者發生嚴重COVID-19感染風險更高。
2.英國醫學期刊(BMJ)亦報導多位醫師與科學家主張不應服用ibuprofen，應改用paracetamol。
3.但WHO在官方推特表示，尚未看到該藥已知的一般副作用以外的負面影響的報告，基於目前資訊，「不使用ibuprofen」並不是WHO目前的立場。
4.英國NHS亦表示尚無強烈證據，但在證據明確前，建議先避免使用ibuprofen，優先改用paracetamol；若已正在服用ibuprofen，勿未經諮詢醫師直接停藥。
■「ibuprofen等抗炎藥加重COVID-19病情」部分：學界尚無定論：
1.Lancet一篇通訊評論的確提及ibuprofen會增加ACE II促進COVID-19的感染；並認為使用這些藥物治療心臟病、高血壓、糖尿病的患者發生嚴重COVID-19感染風險更高。
2.英國醫學期刊(BMJ)亦報導多位醫師與科學家主張不應服用ibuprofen，應改用paracetamol。
3.但WHO在官方推特表示，尚未看到該藥已知的一般副作用以外的負面影響的報告，基於目前資訊，「不使用ibuprofen」並不是WHO目前的立場。
4.英國NHS亦表示尚無強烈證據，但在證據明確前，建議先避免使用ibuprofen，優先改用paracetamol；若已正在服用ibuprofen，勿未經諮詢醫師直接停藥。
Opinion Sources
2020年3月15日TheJournal.ie報導-引述IDSI貼文指出Cork醫院案為假消息：https://www.thejournal.ie/ibuprofen-cuh-coronavirus-whatsapp-5047311-Mar2020/
2020年3月11日刊在Lancet的通訊評論，第2段提及ibuprofen可能造成的影響：
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/fulltext
2020年3月17日英國醫學期刊報導-多位醫師與科學家認為有COVID-19症狀者不應使用ibuprofen：
https://www.bmj.com/content/368/bmj.m1086
2020年3月19日WHO官方推特-「不使用ibuprofen」並不是WHO目前立場：
https://twitter.com/WHO/status/1240409217997189128/photo/1
英國NHS官網-表示雖尚無強烈證據ibuprofen會加重病情，但在有進一步資訊前建議改用paracetamol為原則：
https://www.nhs.uk/conditions/coronavirus-covid-19/self-isolation-advice/
https://www.thejournal.ie/ibuprofen-cuh-coronavirus-whatsapp-5047311-Mar2020/
Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
The most distinctive comorbidities of 32 non-survivors from a group of 52 intensive care unit patients with novel coronavirus disease 2019 (COVID-19) in the study by Xiaobo Yang and colleagues1Yang X
Covid-19: ibuprofen should not be used for managing symptoms, say doctors and scientists
Scientists and senior doctors have backed claims by France’s health minister that people showing symptoms of covid-19 should use paracetamol (acetaminophen) rather than ibuprofen, a drug they said mig
World Health Organization (WHO) on Twitter: "Q: Could #ibuprofen worsen disease for people with #COVID19? A: Based on currently available information, WHO does not recommend against the use of of ibuprofen. https://t.co/n39DFt2amF" / Twitter
By using Twitter’s services you agree to our Cookies Use. We and our partners operate globally and use cookies, including for analytics, personalisation, and ads.Q: Could #ibuprofen worsen disease for
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